act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB))

PubMed:19126755

Downstream from the nicotine-stimulated kinases, a number of transcription factors have been shown to be activated. Among these factors are the cAMP response element binding protein (CREB) and the activating transcription factor 2 (ATF-2) in PC12 cells (211, 337, 460), the Ets-like transcription factor Elk-1 in the rat hippocampus (349), and the signal transducer and activator of transcription (STAT3) in macrophages and skin cells (114, 354).

Related Edges 3

• act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2))
• act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1))
• act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3))

MeSH

PC12 Cells

Text Location

Review

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