path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")

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PubMed:19293145

Loss of cholinergic neurons has often been demonstrated as lowered ChAT activity in brains of patients with AD. Early post mortem studies indicated a loss of ChAT activity restricted to the neocortex (Slotkin et al., 1990) and this has been confirmed in more recent studies on frontal lobe and temporal cortex (Lai et al., 2006). It is noteworthy that an increase in ChAT activity in the surviving neurons was interpreted as a possible compensatory mechanism (Slotkin et al., 1990).

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• a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT))

MeSH

Frontal Lobe

MeSH

Neocortex

MeSH

Temporal Lobe

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