complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(GO:"glutamatergic synapse"))

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PubMed:26631930

In addition, dendritic tau could serve as a protein scaffold to deliver the kinase FYN to postsynaptic sites, where FYN phosphorylates subunit 2 of the NMDA receptor (NR2B; also known as GluN2B), resulting in the stabilization of the interaction of this receptor interaction with postsynaptic density protein 95 (PSD95; also known as DLG4), potentiating glutamatergic signalling and thereby enhancing Aβ toxicity.

Related Edges 5

• p(HGNC:MAPT) increases act(a(CHEBI:"amyloid-beta"))
• p(HGNC:MAPT) increases complex(p(HGNC:DLG4), p(HGNC:FYN))
• complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(CHEBI:"amyloid-beta"))
• p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(Ph))
• p(HGNC:GRIN2B, pmod(Ph)) increases complex(p(HGNC:DLG4), p(HGNC:FYN))

MeSH

Dendritic Spines

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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