path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex"))

View Subject View Object

PubMed:24561250

Spinal cord injury causes IL-18 and IL-1β release from neuronal cells through the activation of the NLRP1 inflammasome, composed of receptor NLRP1, adaptor protein ASC, caspase-1, caspase-11 and X-linked inhibitor of apoptosis protein (de Rivero Vaccari et al., 2008)

Related Edges 4

• act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B))
• act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18))
• path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18))
• path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B))

Confidence

High

MeSH

Neurons

NeuroMMSigDB

Interleukin signaling subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---