complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases path(HBP:neurotoxicity)

PubMed:19293145

Paradoxically, in addition to their neuroprotective action, nAChRs may also partly mediate the toxic action of Abeta. The toxicity of Abeta on SH-SY5Y cells, as measured by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, in which the health of cells is monitored by their ability of cells to reduce 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide, was significantly impaired when alpha7 was silenced by RNAi, suggesting that Abeta may exert its toxicity, at least in part, through a pathway that includes alpha7 nAChRs (Qi et al., 2007).

Experimental Factor Ontology (EFO)

SH-SY5Y

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