a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

PubMed:19126755

The nicotinic APL action of galantamine appears to be an important determinant of its clinical effectiveness (reviewed in Refs. 98, 291, 371). Acting primarily as a nicotinic APL, galantamine improves synaptic transmission and decreases neurodegeneration, two effects essential for its cognitive-enhancing properties (40, 108, 241, 409, 521).

Related Edges 2

• a(CHEBI:galanthamine) decreases path(HBP:Neurodegeneration)
• a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic")

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