act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau aggregates"))

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PubMed:24027553

Tubulin was later identified as a substrate for HTRA1, suggesting HTRA1 may be involved in mediating microtubule function (42, 43). A more recent study showed that HTRA1 can cleave recombinant tau in vitro into multiple fragments of varying sizes, and furthermore can degrade insoluble and fibrillarized tau (16).

Related Edges 5

• act(a(MESH:Microtubules)) association act(p(HGNC:HTRA1))
• act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT))
• act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins))
• act(p(HGNC:HTRA1)) association act(a(MESH:Microtubules))
• act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau fibrils"))

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