path(MESH:"Alzheimer Disease") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))

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PubMed:19293145

Several lines of evidence point to a link between brain nAChRs and the development of AD. Biochemical analysis of brains of patients with AD reveals deficits in nAChRs, an increase in butyrylcholinesterase, reduction in ACh, and attenuated activity of cholinergic synthetic [choline acetyltransferase (ChAT)] and inactivating (AChE) enzymes (Bartus et al., 1982; Francis et al., 1999).Butyrylcholinesterase and AChE help terminate ACh signaling by hydrolyzing the transmitter, thereby inactivating it.

Related Edges 6

• p(HGNC:ACHE) decreases a(CHEBI:acetylcholine)
• p(HGNC:BCHE) decreases a(CHEBI:acetylcholine)
• path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE)
• path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine)
• path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT))
• path(MESH:"Alzheimer Disease") decreases act(a(MESH:"Cholinesterase Inhibitors"))

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