act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine))

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PubMed:19293145

Nicotine induced phosphorylation of STAT-3 (signal transducer and activator of transcription 3) in peritoneal macrophages is mediated by an alpha7-dependent activation of JAK-2, as part of the anti-inflammatory action of vagal nerve stimulation (de Jonge et al., 2005).

Related Edges 2

• act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(Ph))
• act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2))

Cell Ontology (CL)

peritoneal macrophage

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