a(CHEBI:probenecid) decreases p(HGNC:IL1B)

View Subject View Object

PubMed:24561250

Probenecid, an inhibitor of pannexin 1, has been shown to significantly inhibit the expression and activation of the NLRP2 inflammasome, and the maturation of bothIL-1β and IL-18 in human astrocytes induced by ATP (Minkiewicz et al., 2013)

Related Edges 6

• a(CHEBI:probenecid) decreases p(HGNC:PANX1)
• a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
• a(CHEBI:probenecid) decreases p(HGNC:IL18)
• p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2))
• p(HGNC:PANX1) increases p(HGNC:IL1B)
• p(HGNC:PANX1) increases p(HGNC:IL18)

Cell Ontology (CL)

astrocyte

Confidence

Medium

NeuroMMSigDB

Interleukin signaling subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---