a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT))

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PubMed:24027553

Similarly, overexpressing the FTDP-17 mutant P301L tau in SH-SY5Y cells and then treating with lactacystin led to significantly increased tau levels (70). Lactacystin also caused accumulation of endogenous tau in the HT22 murine neuronal cell line (71). In immortalized mouse cortical neuronal cells inducibly expressing full-length wild-type tau, EPX slowed the degradation of full-length tau (72).

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• a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L"))

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