p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation p(FPLX:PKA)

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PubMed:17078951

Here, we found that prephosphorylation by PKA promotes GSK-3beta-catalyzed tau phosphorylation at Thr181, Ser199, Ser202, Thr205, Thr217, Thr231, Ser396 and Ser422, but inhibits its phosphorylation at Thr212 and Ser404. In contrast, the prephosphorylation had no significant effect on its subsequent phosphorylation by cdk5 at Thr181, Ser199, Thr205, Thr231 and Ser422; inhibited it at Ser202, Thr212, Thr217 and Ser404; and slightly promoted it at Ser396.

Related Edges 44

• act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
• act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
• act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
• act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
• act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
• act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202)))
• act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212)))
• act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217)))
• act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404)))
• act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396)))
• p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(FPLX:PKA)
• p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(FPLX:PKA)
• p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(FPLX:PKA)
• p(HGNC:MAPT, pmod(Ph, Thr, 212)) negativeCorrelation p(FPLX:PKA)
• p(HGNC:MAPT, pmod(Ph, Thr, 217)) positiveCorrelation p(FPLX:PKA)
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181))
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199))
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205))
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 217))
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231))
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
• p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
• p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))
• p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 212))
• p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202)))
• p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212)))
• p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217)))
• p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404)))
• p(FPLX:PKA) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396)))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 217))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 212))
• p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(FPLX:PKA)
• p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(FPLX:PKA)
• p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(FPLX:PKA)
• p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(FPLX:PKA)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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