a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(HBP:"APP processing")

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PubMed:24590577

After brucine, several other M1-PAMs have been discovered, including VU0029767, VU0090157, and benzyl quinolone carboxylic acid (BQCA)[115-117]. These compounds do not activate M1 mAChR directly but greatly increase the affi nity of ACh for the M1 subtype. In addition, BQCA is effective in restoring discrimination reversal learning in a mouse model of AD and regulating nonamyloidogenic APP processing[117].

Related Edges 4

• a(HBP:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1))
• a(HBP:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1))
• a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1))
• a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning)

MeSH

Alzheimer Disease

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