path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5)

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PubMed:8282104

Thus, we now know three kinases, cdk5, MAP kinase, and GSK-3, all of which are present in neurons, which are capable of transforming tau into the Alzheimer-like state, and therefore could account for the pathological phosphorylation of tau in Alzheimer brains

Related Edges 10

• p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph))))
• p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph))))
• p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph))))
• p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:ERK)
• path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:GSK3)

Confidence

High

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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