a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna4)

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PubMed:19293145

Intracerebral injection of Abeta into rats resulted in a loss of alpha4 and alpha7 subunits as measured by Western blotting but an increase in alpha7 mRNA (Liu et al., 2008), again suggesting that Abeta directly reduces expression of alpha7 nAChRs through mechanisms other than reduced mRNAproduction, although caution should be exercised in interpreting quantitative data from Western blot studies. It is noteworthy that a combined patch-clamp and in situ hybridization study of dissociated human brain tissue (obtained as route-of-access tissue removed during surgery) indicated that neurons near Abeta plaques retained alpha4 and alpha7 mRNA transcripts, whereas these transcripts were absent in neurons burdened with hyperphosphorylated tau protein (Wevers et al., 1999).

Related Edges 4

• a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna7)
• a(CHEBI:"amyloid-beta") increases r(RGD:Chrna7)
• path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4)
• path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7)

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