act(p(HGNCGENEFAMILY:Calpains)) increases path(HBP:Neurodegeneration)

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PubMed:24027553

On the one hand, expressing a 17-kDa fragment of tau based on calpain cleavage site mapping in hippocampal neurons led to neurite retraction and the appearance of varicosities after 48 h (52). Additionally, suppressing calpain activity in a fly model of tauopathy prevented neurodegeneration, as did expressing a calpain-resistant form of tau (54).

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• p(HGNC:MAPT, frag("?", "17kD")) increases bp(HBP:"neurite retraction")

MeSH

Tauopathies

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