p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))

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PubMed:24653673

Significantly, downregulation of LCMT1 expression leads to a significant decrease of PP2A methylation and concomitant loss of PP2A holoenzymes containing the regulatory Bα (or PPP2R2A) subunit (PP2A/Bα; Lee and Pallas,2007; Sontag et al.,2008; MacKay et al.,2013).

Related Edges 3

• p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))
• p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309))
• p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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