p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3))

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PubMed:22908190

Third, there is ligation of Ub with an epsilon-amino group of lysine in the target protein by an E3 ligase. E3 ligase binds both the target protein and the E2–Ub complex; thousands of substrate- specific E3s ensure selective protein tagging and degradation.

Related Edges 2

• p(MESH:Proteins, pmod(Ub)) increases deg(p(MESH:Proteins, pmod(Ub)))
• complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(Ub))

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