act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT))

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PubMed:24027553

Evidence supporting a role for thrombin in tau proteolysis came initially from an in vitro study showing that thrombin degraded recombinant full-length tau from the N-terminus yielding a 25-kDa fragment, while preserving the microtubule binding repeat domain (13).

Related Edges 2

• act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?"))
• act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685"))

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