act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT))

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PubMed:24027553

In M1C neuroblastoma cells that inducibly express full-length wild-type tau (4R0N), treatment with CQ also significantly slowed down tau degradation, and caused its accumulation (92). Treatment of hippocampal slices with the cathepsin modulator ZPAD (which stimulates cathepsin D very strongly) appears to increase the proteolysis of full-length tau resulting in the production of smaller fragments, including a phosphorylated 29 kDa fragment (86, 89). This partial degradation of tau was inhibited by inclusion of a selective cathepsin D inhibitor (86).

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• a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT))
• act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"), pmod(Ph))

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