act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1)

View Subject View Object

PubMed:25784053

This process allows active IRE1 to cleave XBP1 messenger RNA (mRNA), thereby generating a spliced transcript (XBP1s) that encodes a stable form of XBP1 that binds DNA and induces transcription of UPR target genes (8).

Related Edges 1

• act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---