path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")

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PubMed:19293145

AD involves loss of cholinergic cells not only in the cortex but also in subcortical nuclei. Up to 50% loss of neurons and of ChAT activity has been reported at autopsy in the locus ceruleus of brains from patients with AD compared with brains from subjects without AD, whereas no change was observed for adrenergic brainstem nuclei (Strong et al., 1991).

Related Edges 1

• path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT))

MeSH

Basal Ganglia

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