p(HGNC:AMBP)
to a(CHEBI:heme)
The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23].
p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme)
cf2506e1f6
Furthermore, the plasmaand extravascular reductase and heme- and radical scavenger α1-microglobulin (A1M) binds and degrades free heme and can reduce metHb [28–30].
p(HGNC:AMBP) increases deg(a(CHEBI:heme))
44887c72f9
Excess extracellular heme is weakly bound to albumin [22], /1-microglobulin (which can also degrade heme) [23] and, most likely, to other plasma proteins and lipoproteins; there is a dynamic nature to such interactions.
p(HGNC:AMBP) decreases a(CHEBI:heme)
0ce64aa809
Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011).
p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme)
e4ed9656d8
This is consistent with our findings here that both heme and Hb were associated with increased levels of synovial fluid A1M.
p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme)
e792178355
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