PubMed 24489717

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23].

BEL
p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme)
Hash
cf2506e1f6
TextLocation
Introduction
Networks

PubMed 26368565

Furthermore, the plasmaand extravascular reductase and heme- and radical scavenger α1-microglobulin (A1M) binds and degrades free heme and can reduce metHb [28–30].

BEL
p(HGNC:AMBP) increases deg(a(CHEBI:heme))
Hash
44887c72f9
Cell
hepatocyte
MeSHAnatomy
Placenta
TextLocation
Introduction
Networks

PubMed 26875449

Excess extracellular heme is weakly bound to albumin [22], /1-microglobulin (which can also degrade heme) [23] and, most likely, to other plasma proteins and lipoproteins; there is a dynamic nature to such interactions.

BEL
p(HGNC:AMBP) decreases a(CHEBI:heme)
Hash
0ce64aa809
TextLocation
Review
Networks

PubMed 30505280

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011).

BEL
p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme)
Hash
e4ed9656d8
MeSHAnatomy
Synovial Fluid
MeSHDisease
Osteoarthritis, Knee
TextLocation
Discussion
Networks

PubMed 30505280

This is consistent with our findings here that both heme and Hb were associated with increased levels of synovial fluid A1M.

BEL
p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme)
Hash
e792178355
MeSHAnatomy
Synovial Fluid
MeSHDisease
Osteoarthritis, Knee
TextLocation
Discussion
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.