PubMed 25784053

Additionally, an investigation of chaperone and cochaperone gene expression in young (36±4 years of age) and aged (73 ±4 years of age) human brain tissue revealed that of 332 genes examined, 101 are significantly repressed with age, including HSP70, HSP40, HSP90, and TRiC genes (113). Furthermore, 62 chaperone genes, including several small HSPs, were found to be significantly induced, likely as a result of the cellular response to accumulating protein damage with age (113).

BEL
bp(MESH:Aging) decreases p(FPLX:HSP90)
Hash
d478cb7b2c
Cell
motor neuron
Networks

PubMed 29311797

One study focused on the basal levels of cytosolic Hsp90 in peripheral blood mononuclear cells (PBMC) and found that in aged human samples there was an increase in Hsp90 under normal physiological conditions when compared to young samples (Njemini et al., 2007).

BEL
bp(MESH:Aging) increases p(FPLX:HSP90)
Hash
2cf0df586a
Cell
peripheral blood mononuclear cell
Networks

PubMed 29311797

Conversely, there are also studies showing decreased levels of Hsp90 in aged human brain samples.

BEL
bp(MESH:Aging) decreases p(FPLX:HSP90)
Hash
e31cf7a8bc
MeSHAnatomy
Brain
Networks

PubMed 29311797

One study found that cytosolic Hsp90 was repressed in the superior frontal gyrus, while another demonstrated a similar repression in the prefrontal cortex of aged patients compared to controls (Berchtold et al., 2008; Loerch et al., 2008; Brehme et al., 2014).

BEL
bp(MESH:Aging) decreases p(FPLX:HSP90)
Hash
bac622bce0
Anatomy
prefrontal cortex, superior frontal gyrus
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.