PubMed 24027553

There may be reciprocity with the apoptosis pathway as activating caspase-3 by inducing apoptosis in cortical neuronal culture led to tau cleavage (22), and selectively expressing tauC3 led to apoptosis in NT2 and COS cells (21). This might represent a feed-forward loop of neurotoxicity.

BEL
bp(GO:"apoptotic process") increases act(p(HGNC:CASP6))
Hash
54fd8643d2
TextLocation
Review
Networks

PubMed 24027553

Caspase-6 was also shown to cleave the N-terminus of tau in vitro (24). Caspase-3, which is a key effector in the apoptotic cascade, cleaves tau predominantly at the C-terminal D421 site generating a fragment often referred to as tauC3 (22, 23).

BEL
act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process")
Hash
157ff24109
TextLocation
Review
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.