complex(GO:"NF-kappaB complex")
to p(HGNC:IL6)
NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself
complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
d7cb8904a8
p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex"))
cf48b07cdf
IL6 is another NF-κB – induced [256-260] pro-inflammatory cytokine up-regulated and integrally involved in the etio-pathogenesis of Alzheimer’s disease
complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
63fb99e9ff
Furthermore, NF-κB - induced IL6 has been demonstrated to evoke hyperphosphorylation of tau at Ser202 and Thr205 via the activation of the cdk5/p35 complex
complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
63eaa6fbb5
Amyloid-β also induces microglial activation that results in NF-κB – induced expression of pro-inflammatory cytokines such as TNFα, IL1β, IL6, and IL8 from the microglia resulting in neuronal death
complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
9e63b67968
Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients
complex(GO:"NF-kappaB complex") increases p(HGNC:IL6)
cbec684920
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.