complex(GO:"NF-kappaB complex")
to p(HGNC:BCL2L1)
Recent evidence has cogently shown that Amyloid-β induces apoptosis in rat primary neurons and human post-mitotic neuronal cells by reducing Bcl-XL expression level and evoking the release of cytochrome c from the mitochondria in a NF-κB – dependent manner
complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1)
1699269cd2
This is counter-intuitive as it is established that NF-κB positively regulates the expression of Bcl-XL and other members of the Bcl2 family
complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1)
5078b7cefa
The anti-apoptotic effects of NF-κB have been ascribed to its ability to trans-activate the expression of a multitude of anti-apoptotic genes such as Bcl-2, Bcl-XL, and Bfl-1/A1 in the neurons of the amygdala, olfactory bulb, and the CA1/CA3 region of the hippocampus
complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1)
87d76847fd
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.