a(MESH:"Neurofibrillary Tangles")
to p(HGNC:MAPT)
AD is characterized pathologically by the occurrence of intracellular neurofibrillary tangles rich in tau protein and extracellular plaques containing amyloid peptides (Price et al., 1991).
a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT)
3a1b956663
p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles")
ecbe3d8b25
In contrast, the neurofibrillary tangles are intracellular and are rich in tau, a structural protein that is normally associated with microtubuli
a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT)
ffe607dab2
p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles")
133de7b50f
In conjunction with the formation of neurofibrillary tangles, the synthesis of the tau protein increases, and it undergoes an abnormal posttranslational modification characterized by hyperphosphorylation
a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT)
8ea693af83
In severe AD cases (i.e. Braak stage V-VI), all markers continue to colocalize in classic NFTs within the hippocampus that characterize AD tau pathology (Fig. 5E–H)
a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT)
6f4ddf15b2
p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles")
0c994eeac3
Proteolytic processing/degradation of tau is also believed to be important for the formation of the neurofibrillary tangles,although the molecular pathways involved in this process are not fully understood
deg(p(HGNC:MAPT)) increases a(MESH:"Neurofibrillary Tangles")
9694d26d0b
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.