PubMed 24630724

Notably, heme mediated induction of SPIC-EGFP+ BMDM was significantly reduced with Bach1 overexpression suggesting that Bach1 may inhibit Spic expression (Figure 5C).

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p(MGI:Bach1) decreases p(MGI:Spic)
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3e85f4d31d
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PubMed 24630724

Here we showed that Bach1 was a transcriptional repressor of Spic and that heme-induced proteasome-dependent degradation of BACH1 protein in monocytes led to Spic expression and promoted RPM and BMM development (Figure 7F).

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p(MGI:Bach1) decreases p(MGI:Spic)
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c576418dd7
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deg(p(MGI:Bach1)) increases p(MGI:Spic)
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a67c22fc3c
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.