PubMed 26794659

In agreement with the electrical cell–substrate impedance sensing data described above, the proteome changes triggered by 10 μM heme were indicative of an adaptive response with prominent induction of HMOX1 and ferritin light (FTL) and heavy (FTH1) chains (Figure 5d,left panel).

BEL
a(CHEBI:heme) increases p(HGNC:FTH1)
Hash
eefc778b40
Cell
epithelial cell
Concentration
10 μM
MeSHAnatomy
Kidney
Species
Cavia porcellus
TextLocation
Results
TimePoint
4 hours
Networks

PubMed 24904418

Cells deficient on FtH are more susceptible to oxidative damage, while increased amounts of FtH protects cells from death induced by challenges such as Fe, tumor necrosis factor (TNF), heme, heme plus TNF, or oxidized low-density lipoprotein (LDL; Juckett et al., 1995; Pham et al., 2004; Gozzelino et al., 2012).

BEL
p(HGNC:FTH1) decreases a(CHEBI:heme)
Hash
ef0a92d969
TextLocation
Review
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.