PubMed 24464629

Free heme is a dangerous molecule which can be recognized and degenerated by stress-responsive enzyme oxygenase- 1 (HO-1) [16] which plays an essential role in host defense against heme.

BEL
deg(a(CHEBI:heme)) positiveCorrelation p(HGNC:HMOX1)
Hash
a3ed094e6d
MeSHAnatomy
Kidney
TextLocation
Introduction
Networks
BEL
p(HGNC:HMOX1) positiveCorrelation deg(a(CHEBI:heme))
Hash
7e162a6eff
MeSHAnatomy
Kidney
TextLocation
Introduction
Networks

PubMed 24553061

Lysis of red blood cells with consequent increases in free heme most likely caused the increase in HO-1 activity responsible for increased COHb concentrations, which is similar to that observed with circulatory devices [6].

BEL
a(CHEBI:heme) positiveCorrelation act(p(HGNC:HMOX1))
Hash
7b826f33ac
TextLocation
Discussion
Networks
BEL
act(p(HGNC:HMOX1)) positiveCorrelation a(CHEBI:heme)
Hash
19b72761bd
TextLocation
Discussion
Networks

PubMed 24904418

Importantly, heme b interaction with heme oxygenase (HO; Lad et al., 2003), the enzyme responsible for heme intracellular catabolism, and hemopexin (Hx; Paoli et al., 1999), a plasmatic heme scavenger, is essential for the regulation of free heme availability and Fe recycling (Kovtunovych et al., 2010; Tolosano et al., 2010).

BEL
deg(a(CHEBI:heme)) positiveCorrelation p(HGNC:HMOX1)
Hash
2e9fae7461
TextLocation
Review
Networks
BEL
p(HGNC:HMOX1) positiveCorrelation deg(a(CHEBI:heme))
Hash
507b9f3214
TextLocation
Review
Networks

PubMed 26675351

Consistently, CD11b cells (granulocytes and monocytes) and iron-rich cells (macrophages) isolated from heme-treated Hx-null mice show a higher heme content and increased mRNA and protein expression of HO-1, Lferritin, and Fpn (Figure 1B-G) and elevated mRNA levels of the proinflammatory cytokine IL-6 ( Figure 1H).

BEL
a(CHEBI:heme) increases p(HGNC:HMOX1)
Hash
eac48ff571
MeSHAnatomy
Liver
MeSHDisease
Anemia, Sickle Cell
TextLocation
Results
Networks

PubMed 26794659

In agreement with the electrical cell–substrate impedance sensing data described above, the proteome changes triggered by 10 μM heme were indicative of an adaptive response with prominent induction of HMOX1 and ferritin light (FTL) and heavy (FTH1) chains (Figure 5d,left panel).

BEL
a(CHEBI:heme) increases p(HGNC:HMOX1)
Hash
e040313002
Cell
epithelial cell
Concentration
10 μM
MeSHAnatomy
Kidney
Species
Cavia porcellus
TextLocation
Results
TimePoint
4 hours
Networks

PubMed 26875449

Despite its damaging effects, heme induces the expression of HO-1, which degrades heme to anti-inflammatory, cytoprotective, and antioxidant products [25].

BEL
a(CHEBI:heme) increases p(HGNC:HMOX1)
Hash
028d4091c2
Cell
erythrocyte
MeSHAnatomy
Serum
MeSHDisease
Malaria
TextLocation
Review
Networks
BEL
p(HGNC:HMOX1) increases deg(a(CHEBI:heme))
Hash
38b1c604ed
Cell
erythrocyte
MeSHAnatomy
Serum
MeSHDisease
Malaria
TextLocation
Review
Networks

PubMed 26875449

A recent Phase IIB clinical trial showed that preconditioning using hemin upregulated HO-1 in renal transplantation, launching further studies on clinical outcome [97].

BEL
a(CHEBI:heme) increases p(HGNC:HMOX1)
Hash
80d07663d7
Cell
erythrocyte
MeSHAnatomy
Serum
MeSHDisease
Malaria
TextLocation
Review
Networks

PubMed 27125525

CD163 mediated hemoglobin/hematoma clearance is involved in the induction of HO-1, a rate-limiting enzyme for heme degradation 26.

BEL
deg(a(CHEBI:heme)) positiveCorrelation p(HGNC:HMOX1)
Hash
a1dbc35c03
Cell
macrophage
MeSHDisease
Cerebral Hemorrhage
TextLocation
Discussion
TimePoint
3 days
Networks
BEL
p(HGNC:HMOX1) positiveCorrelation deg(a(CHEBI:heme))
Hash
33880219fa
Cell
macrophage
MeSHDisease
Cerebral Hemorrhage
TextLocation
Discussion
TimePoint
3 days
Networks

PubMed 28716864

As predicted, HMOX1 expression levels (means 6 SD) in hemin-treated cells were much higher (7.25 6 5.02, n = 12; P , 0.001) than in nontreated controls (0.14 6 0.18, n = 9) or A1AT-treated cells (0.09 6 0.1, n = 9).

BEL
a(CHEBI:heme) positiveCorrelation p(HGNC:HMOX1)
Hash
292ff94f5c
Cell
neutrophil
TextLocation
Results
Networks
BEL
p(HGNC:HMOX1) positiveCorrelation a(CHEBI:heme)
Hash
fa2fedaf90
Cell
neutrophil
TextLocation
Results
Networks

PubMed 26368565

In the extravascular compartment, cellular heme oxygenase (HO) is the most essential heme degrading protein, converting heme to free iron, biliverdin and CO [26,27].

BEL
p(HGNC:HMOX1) increases deg(a(CHEBI:heme))
Hash
ca3e02ac8c
Cell
hepatocyte
MeSHAnatomy
Placenta
TextLocation
Introduction
Networks

PubMed 30248094

Upon degradation of RBCs in the erythrophagosome, heme is imported into the cytoplasm for degradation by the heme-degrading enzyme heme oxygenase-1 (HMOX1) [7].

BEL
p(HGNC:HMOX1) increases deg(a(CHEBI:heme))
Hash
9a786b921f
MeSHAnatomy
Cytoplasm
Species
Danio rerio
TextLocation
Introduction
Networks

PubMed 30505280

A major intracellular antioxidant is heme oxygenase-1 (HO-1) which, through its heme-degrading activity, plays a critical role in the protection of cells.

BEL
p(HGNC:HMOX1) increases deg(a(CHEBI:heme))
Hash
91fb48238c
MeSHAnatomy
Knee
MeSHDisease
Osteoarthritis, Knee
TextLocation
Introduction
Networks

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.