p(MGI:Hmox1)
to a(CHEBI:heme)
Mice lacking HO-1 (Hmox1−/−) are highly susceptible to pathologic conditions associated with increased serum heme concentration.
p(MGI:Hmox1) decreases a(CHEBI:heme)
5629c85b6d
The results showed that enforced HO-1 could efficiently decline the heme level in the lysates of ligated kidneys, and inhibit kidney inflammation characterized by down-regulation of NLRP3-Caspase- 1-IL-1b axis.
p(MGI:Hmox1) negativeCorrelation a(CHEBI:heme)
03c2bedae8
The Hmox1 (− /− ) MEF cells expressed no functional Hmox1 mRNA (Figure 1a) and as a result accumulated more cell-associated heme during extracellular exposure compared with wild-type cells (Figure 1b).
p(MGI:Hmox1) negativeCorrelation a(CHEBI:heme)
18fa260528
Macrophages are crucial for the removal of excess heme resulting from hemolysis via the uptake and degradation of heme by HO-1 (ref. 23), encoded by Hmox1.
p(MGI:Hmox1) increases deg(a(CHEBI:heme))
b2df7e6072
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