PubMed 24904418

Mice lacking HO-1 (Hmox1−/−) are highly susceptible to pathologic conditions associated with increased serum heme concentration.

BEL
p(MGI:Hmox1) decreases a(CHEBI:heme)
Hash
5629c85b6d
Cell
erythrocyte
TextLocation
Review
Networks

PubMed 24464629

The results showed that enforced HO-1 could efficiently decline the heme level in the lysates of ligated kidneys, and inhibit kidney inflammation characterized by down-regulation of NLRP3-Caspase- 1-IL-1b axis.

BEL
p(MGI:Hmox1) negativeCorrelation a(CHEBI:heme)
Hash
03c2bedae8
Cell
macrophage
MeSHAnatomy
Kidney
Species
Mus musculus
TextLocation
Results
TimePoint
12 hours
Networks

PubMed 25301065

The Hmox1 (− /− ) MEF cells expressed no functional Hmox1 mRNA (Figure 1a) and as a result accumulated more cell-associated heme during extracellular exposure compared with wild-type cells (Figure 1b).

BEL
p(MGI:Hmox1) negativeCorrelation a(CHEBI:heme)
Hash
18fa260528
TextLocation
Results
Networks

PubMed 27798618

Macrophages are crucial for the removal of excess heme resulting from hemolysis via the uptake and degradation of heme by HO-1 (ref. 23), encoded by Hmox1.

BEL
p(MGI:Hmox1) increases deg(a(CHEBI:heme))
Hash
b2df7e6072
Cell
macrophage
TextLocation
Results
Networks

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.