p(FPLX:NFkappaB)
to p(HGNC:TNF)
Then the stimulation of RAGE is able to activate the mitogen-activated protein kinase signaling cascades which converge in IκB kinase complex to phosphorylate IκB, thereby release and activate NF-κB, thus trigger NF-κB dependent gene transcription including IL-1β and TNF-α, which in turn induce the translocation of NF-κB to the nucleus [50].
act(p(FPLX:NFkappaB)) increases p(HGNC:TNF)
58419c825b
p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
9a48f4b57e
Our data clearly demonstrate that NSAIDs inhibit TNF-a-induced BACE1 transcription via its NF-kB cis-acting elements.
p(HGNC:TNF) increases act(p(FPLX:NFkappaB), ma(tscript))
0793de5bba
It inhibited the activation of NF-B in TNF- induced HepG2 cells [193].
p(HGNC:TNF) increases act(p(FPLX:NFkappaB))
8096ae42bf
Nuclear local- ization of NF-κB in differentiated neuron progenitor cells (NPCs) is in- creasing following exposure to IL-1β and TNF-α, strong inducers of the NF-κB pathway with increase in the phosphorylation of IKK and p65 while decrease in the level of IκB [32].
p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
073db38a1f
NSAIDs inhibit BACE1 tran- scriptional activation induced by strong NF-κB activator TNF-α.
p(HGNC:TNF) increases act(p(FPLX:NFkappaB))
df1c3e51b5
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.