a(CHEBI:"amyloid-beta")
to complex(GO:"NF-kappaB complex")
Recent evidence has cogently shown that Amyloid-β induces apoptosis in rat primary neurons and human post-mitotic neuronal cells by reducing Bcl-XL expression level and evoking the release of cytochrome c from the mitochondria in a NF-κB – dependent manner
a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
2c13e451d9
Furthermore, fibrillar Amyloid-β has been shown to activate NF-κB via the assembly pf the C5b-MAC complex
a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
9c366faec6
Furthermore, Amyloid-β actuates NF-κB – dependent pro-inflammatory pathways in microglia culminating in TNFα expression and subsequently TNFα effectuated neurotoxicity
a(CHEBI:"amyloid-beta") increases complex(GO:"NF-kappaB complex")
63f5462540
In primary neuronal cultures, Amyloid-β has been shown to elicit oxidative stress and evoke NF-κB activation
a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
46c7833876
Furthermore, Amyloid-β –induced NF-κB also results in the up-regulation of the antioxidant mitochondrial membrane enzyme – MnSOD (superoxide dismutase 2) [328] which is well known to combat oxidative stress and apoptosis
a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
3da0f1bc11
Under physiological conditions activation of NF-κB by endogenous Aβ reduces βAPP, BACE1 and the γ-secretase activity, thereby lowering Aβ processing and facilitating Aβ homeostasis
a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
a7f1945587
However in AD, exposure to high Aβ concentrations upregulates NF-κB activation increasing βAPP and Aβ processing, precipitating a feed-back loop that favor exacerbated Aβ production
a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex"))
bce2aea2e6
Mechanistically, the Aβ induced neuronal apoptosis has been attributed to the increase in the ratio of proapoptotic gene (BAX) transcription to that of the anti-apoptotic gene Bcl-Xl, and/or to the reduction in constitutively activated NF-κB with consequent increase in the cytoplasmic IκB proteins
a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex"))
a94888bfb5
This is supported by the observation that in mixed neuronal-glial cell cultures, Aβ induces increasing degree of neurotoxicity in an NF-κB dependent manner in the presence of higher proportion of glial cells
a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
74534872e2
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.