PubMed 25307023

Normally, haemopexin safely transports haem away from the vessel wall to ligate LRP1 (also termed CD91) on hepatocytes and macrophages, where the haem–haemopexin complex is endocytosed and haem is degraded intracellularly (Hvidberg et al, 2005).

BEL
p(HGNC:LRP1) increases deg(complex(a(CHEBI:heme), p(HGNC:HPX)))
Hash
bfedf1b9e3
Cell
macrophage
TextLocation
Review
Networks

PubMed 26368565

Free heme in blood is sequestered by hemopexin (Hpx) [23,24] and the Hpx-heme complex is cleared from the circulation by the hepatocyte receptor CD91 [25].

BEL
p(HGNC:LRP1) decreases complex(a(CHEBI:heme), p(HGNC:HPX))
Hash
4c45320595
Cell
hepatocyte
MeSHAnatomy
Placenta
TextLocation
Introduction
Networks

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.