p(HGNC:LRP1)
to complex(a(CHEBI:heme), p(HGNC:HPX))
Normally, haemopexin safely transports haem away from the vessel wall to ligate LRP1 (also termed CD91) on hepatocytes and macrophages, where the haem–haemopexin complex is endocytosed and haem is degraded intracellularly (Hvidberg et al, 2005).
p(HGNC:LRP1) increases deg(complex(a(CHEBI:heme), p(HGNC:HPX)))
bfedf1b9e3
Free heme in blood is sequestered by hemopexin (Hpx) [23,24] and the Hpx-heme complex is cleared from the circulation by the hepatocyte receptor CD91 [25].
p(HGNC:LRP1) decreases complex(a(CHEBI:heme), p(HGNC:HPX))
4c45320595
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.