Evidences p(HGNC:CD163) to a(MESH:"haptoglobin-hemoglobin complex")

The haptoglobin–haemoglobin complex is recognized by the haemoglobin scavenger receptor, CD163, on the surface of monocytes/macrophages, which mediates haptoglobin–haemoglobin endocytosis and degradation (Kristiansen et al, 2001).

Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22].

Haptoglobin binds to hemoglobin dimers and forms a high-molecular weight haptoglobin-hemoglobin complex, which is cleared from the circulation after binding to the CD163 receptor on hepatic and splenic macrophages (12).

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.