Evidences a(CHEBI:"amyloid-beta polypeptide 42") to p(ECCODE:"2.7.11.31")

Interestingly, treatment with Ab42 decreased the phosphorylation of AMPK at Thr172, whereas the total amount of AMPK was not altered in primary cortical neurons

We found, in addition, that enzyme activity of AMPK was sup- pressed in the cortical neurons after exposure to Ab42

These results indicate that AMPK activity is impaired by Ab42 in the neuronal cells in which tau phosphor- ylation increased.

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.