p(MGI:Vegfc)
to a(MESH:"Lymphatic Vessels")
We have previously shown that treatment with recombinant VEGF-C increases the diameter of meningeal lymphatic vessels
p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels")
d792b7440f
Furthermore, delivery of VEGF-C by adenoviral gene therapy was previously found to efficiently boost peripheral lymphatic sprouting and function
p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels"))
e4832fb7e6
Treatment of young mice with AAV1-CM-mVEGF-C resulted in a significant increase in meningeal lymphatic vessel diameter, without affecting blood vessel coverage (Extended Data Fig. 6k–m)
p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels")
97a992dac5
Treatment of old mice (at 20–24 months) with AAV1-CMV-mVEGF-C also resulted in increased lymphatic vessel diameter (compared to AAV1-CMV-eGFP) without detectable off-target effects on the meningeal blood vasculature coverage and on meningeal and/or brain vascular haemodynamics (Fig. 2e–h and Extended Data Fig. 6n–p)
p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels")
cc446254e4
This VEGF-C treatment led to a significant increase in the function of meningeal lymphatic vessels in old mice, whereas young–adult mice did not respond to the treatment (Extended Data Fig. 7d, e), probably due to the ceiling effect of their existing capacity to drain OVA-A647
p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels"))
6f85be8346
Moreover, viral expression of mVEGF-C did not significantly affect the diameter of meningeal lymphatic vessels, the level of amyloid-β in the CSF, or amyloid-β deposition in the hippocampus (Extended Data Fig. 8g–n)
p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels")
1565bd44f0
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.