PubMed 29626319

Transcriptional factor EB downregulates Aβ levels by affecting autophagy-lysosome (Zhang and Zhao 2015)

PubMed 29626319

Xiao et al. have also obtained the consistent conclusion that transcriptional factor EB, a master regulator of lysosome biogenesis, improves lysosomal function in astrocytes, which may promote Aβ clearance and attenuate plaque pathogenesis (Xiao et al. 2014)

BEL
p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta"))
Hash
66051280f7
MeSHAnatomy
Astrocytes
Networks

PubMed 29626319

For example, like Aβ, clearance of pTau/NFT also can be regulated by TFEB, which increases the activity of autophagy and lysosome (Polito et al. 2014)

BEL
p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta"))
Hash
9c2102e31a
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.