PubMed 25784053

IRE1 is a transmembrane protein with kinase and endoribonuclease (RNase) activity that senses misfolding in the ER directly, leading to autophosphorylation, oligomerization, and acquisition of RNase activity (8).

BEL
act(p(HGNC:ERN1), ma(kin)) increases p(HGNC:ERN1, pmod(Ph))
Hash
6212ccbd7f
MeSHAnatomy
Endoplasmic Reticulum
Networks
BEL
p(HGNC:ERN1, pmod(Ph)) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity"))
Hash
d6bdeb971f
MeSHAnatomy
Endoplasmic Reticulum
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.