PubMed 30046111

Similar findings for brain perfusion by CSF were observed when meningeal lymphatic drainage was disrupted by surgical ligation of the vessels afferent to the dCLNs (Extended Data Fig. 3a–d)

BEL
act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation")
Hash
711f63e567
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 30046111

Prospero homeobox protein 1 heterozygous (Prox1+/−) mice, a genetic model of lymphatic vessel malfunction25, also presented impaired perfusion through the brain parenchyma and impaired CSF drainage (Extended Data Fig. 3e–i)

BEL
act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation")
Hash
32d56fb847
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 30046111

Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules

BEL
act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation")
Hash
623c32c50c
Confidence
High
MeSHAnatomy
Brain
Networks
BEL
bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels"))
Hash
466af7b100
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 30046111

The increased drainage after VEGF-C treatment in old mice also correlated with enhanced brain perfusion by CSF macromolecules (Extended Data Fig. 7f, g)

BEL
act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation")
Hash
b846d0f1e1
Confidence
High
MeSHAnatomy
Brain
Networks
BEL
bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels"))
Hash
426aabf588
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 30046111

Impaired brain perfusion by CSF in old mice was accompanied by a decrease in meningeal lymphatic vessel diameter and coverage, as well as decreased drainage of CSF macromolecules into dCLNs in both females and males (Extended Data Fig. 6c–f)

BEL
bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels"))
Hash
348dfb0c67
Confidence
High
MeSHAnatomy
Meninges
Networks

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.