a(MESH:"Lymphatic Vessels")
to bp(MESH:"Cerebrovascular Circulation")
Similar findings for brain perfusion by CSF were observed when meningeal lymphatic drainage was disrupted by surgical ligation of the vessels afferent to the dCLNs (Extended Data Fig. 3a–d)
act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation")
711f63e567
Prospero homeobox protein 1 heterozygous (Prox1+/−) mice, a genetic model of lymphatic vessel malfunction25, also presented impaired perfusion through the brain parenchyma and impaired CSF drainage (Extended Data Fig. 3e–i)
act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation")
32d56fb847
Together, three different models of impaired meningeal lymphatic function (pharmacological, surgical and genetic) showed a significant impact on brain perfusion by CSF macromolecules
act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation")
623c32c50c
bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels"))
466af7b100
The increased drainage after VEGF-C treatment in old mice also correlated with enhanced brain perfusion by CSF macromolecules (Extended Data Fig. 7f, g)
act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation")
b846d0f1e1
bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels"))
426aabf588
Impaired brain perfusion by CSF in old mice was accompanied by a decrease in meningeal lymphatic vessel diameter and coverage, as well as decreased drainage of CSF macromolecules into dCLNs in both females and males (Extended Data Fig. 6c–f)
bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels"))
348dfb0c67
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.