Title

Molecular motors implicated in the axonal transport of tau and alpha-synuclein.

Journal

Journal of cell science

Volume

118

Issue

None

Pages

4645-54

Date

2005-10-15

Authors

Noble WJ | Hill JE | Utton MA | Hanger DP | Anderton BH

By immunoprecipitation, we also found that tau and alpha-synuclein are each associated, either directly or indirectly with complexes containing the fast anterograde motor kinesin-1, and alpha-synuclein is also present in a complex with the fast retrograde motor dynein.In this study, we observed marked differences in the relative associations of tau and alpha-synuclein directly with molecular motors because tau interacts with a kinesin-1 complex binding to KLC1 and KLC2, whereas alpha-synuclein did not bind to either KLC1 or KLC2 under our experimental conditions.

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