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PubMed: 26095350

Title
Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII.
Journal
Aging cell
Volume
14
Issue
None
Pages
754-63
Date
2015-10-01
Authors
Han C | He R | Liu Y | Su T | Wang Y | Wei Y | Wu B

Evidence 958f465de1
JSON

Here, we show for the first time that the administration of D-ribose, the most active glycator among monosaccharides, produces high levels of advanced glycation end products (AGEs) and, importantly, triggers hyperphosphorylation of Tau in the brain of C57BL/6 mouse and neuroblastoma N2a cells.

a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) View Subject | View Object

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Annotations
Uberon
brain

a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:

a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) View Subject | View Object

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a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

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a(CHEBI:"D-ribose") increases a(CHEBI:"advanced glycation end-product") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(MGI:Mapt, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") View Subject | View Object

Appears in Networks:
Annotations
Uberon
brain

Evidence 569789dfe3
JSON

The treatment of 10 mM D-ribose for 24 h resulted in a significant increase in active form of CaMKII (p-Thr286/287), yet simultaneously in a decrease in inactive form of CaMKII (p-Thr305/306) phosphorylation (Fig. 4e). The enzyme activity assay supported this result.

a(CHEBI:"D-ribose") increases p(MGI:Camk2b, pmod(Ph, Thr, 287)) View Subject | View Object

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a(CHEBI:"D-ribose") decreases p(MGI:Camk2b, pmod(Ph, Thr, 306)) View Subject | View Object

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p(MGI:Camk2b, pmod(Ph, Thr, 287)) increases act(p(MGI:Camk2b)) View Subject | View Object

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p(MGI:Camk2b, pmod(Ph, Thr, 306)) decreases act(p(MGI:Camk2b)) View Subject | View Object

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Evidence 714b87df54
JSON

Thus, our results suggest that Tau hyperphosphorylation was a result of ribosylated AGEs, rather than due to a direct reaction involving D-ribose.

a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 214)) View Subject | View Object

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a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.