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PubMed: 22764226

Title
Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume
32
Issue
None
Pages
9173-81
Date
2012-07-04
Authors
Arning E | Bottiglieri T | Nunbhakdi-Craig V | Sontag E | Sontag JM | Wasek B

Evidence ecc7739bbc
JSON

Reductions in PP2A methylation were associated with a concomitant increase in each brain region of p-Tau at the PHF-1 epitope (Fig. 6A,B).

act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me)) View Subject | View Object

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Uberon
blood plasma

a(HBP:"Tau epitope, PHF1") negativeCorrelation p(MGI:Ppp2ca, pmod(Me)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma

p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation a(HBP:"Tau epitope, PHF1") View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma

Evidence ab9b16966e
JSON

Incubation of human SH-SY5Y neuroblastoma cells for 2 h with L-dopa induced a dose-dependent decrease in both soluble and insoluble methylated PP2A C subunit levels, and concomitant accumulation of demethylated PP2A enzymes

act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) View Subject | View Object

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Evidence c73d88e2c6
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Significantly, we found similar effects in human dopaminergic neurons (Fig. 2F). Treatment of neurons with L-Dopa induced a 40–49% decrease in methylated PP2A and concomitant 168–179% increase in endogenous p-Tau (PHF-1) levels (Fig. 2G).

act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dopaminergic cell groups

act(a(CHEBI:"L-dopa")) increases a(HBP:"Tau epitope, PHF1") View Subject | View Object

Appears in Networks:
Annotations
Uberon
dopaminergic cell groups

Evidence 5889979b83
JSON

Folate starvation in the presence of L-dopa resulted in a 200–210% increase in demethylated PP2A levels, and 235–250% increase in p-Tau levels in the dopaminergic neurons, relative to untreated controls maintained in NF medium.

act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") View Subject | View Object

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Uberon
dopaminergic cell groups

a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
dopaminergic cell groups

Evidence 855d91182e
JSON

Here, we found that administration of L-dopa led to a significant 5-fold increase in plasma tHcy concentrations, when compared to saline treated mice (Table 1). This L-dopa induced increase in plasma tHcy was significantly greater in mice that had been reared on either low folate (LF) or FD diets (Table 1).

act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") View Subject | View Object

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Annotations
Uberon
blood plasma

act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine) View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma

a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma

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