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PubMed: 24183963

Title
Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation.
Journal
Neuroscience
Volume
256
Issue
None
Pages
137-46
Date
2014-01-03
Authors
An FM | Chen S | Gao XD | Liu AR | Yao WB | Yin DK | Yin L

Evidence 5c62c48b63
JSON

Recently, Li et al. (2012b) have demonstrated in their study that AGEs can induce tau hyperphosphorylation through receptor for advanced glycation end product (RAGE)-mediated glycogen synthase kinase 3 (GSK-3) activation and targeting RAGE/GSK-3 pathway can improve AD-like changes.

a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) View Subject | View Object

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a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

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act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

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act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

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Evidence 50054d9eb1
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Primary hippocampal neuron cells at different concentrations (0, 50, 100, 200 lg/ml) of glucose–BSA were incubated together for 24 h, and then thr205- phosphorylated tau was estimated by the western immunoblotting method. Western blot analysis of each experimental group showed that glucose–BSA promoted tau thr205-phosphorylation in a concentration-dependent manner (Fig. 3(a)). In the present study, it was also shown that 100 nM GLP-1 or Ex-4 treatment reduced tau hyperphosphorylation induced by glucose–BSA (Fig. 3(b, c)).

a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) View Subject | View Object

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Annotations
Uberon
hippocampal formation

p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) View Subject | View Object

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Annotations
Uberon
hippocampal formation

Evidence def5a078f8
JSON

Western blot analysis of different experimental groups, primary hippocampal neuron cells concurrent treatment with different concentrations (0, 50, 100, 200 lg/ml) of glucose–BSA for 24 h, also showed that glucose–BSA inhibited the phosphorylation of GSK-3b in a concentration-dependent manner (Fig. 4(a)). And 100 nM GLP-1 or Ex-4 can up-regulate phosphorylation of GSK-3b at Ser9, which was decreased by treatment with glucose–BSA (Fig. 4(b, c)).

a(CHEBI:glucose) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

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