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Appears in Networks 5

In-Edges 9

act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) View Subject | View Object

Nicotinic neuroprotection against non-Abeta toxicity is also mediated largely through alpha7 nAChRs. alpha7 nAChRs protect PC12 cells against ethanol toxicity (Li et al., 1999a) and from cell death associated with serum depletion (Ren et al., 2005); they protect cultured neurons against glutamate-induced excitotoxicity (Kaneko et al., 1997) and hippocampal slices against oxygen and glucose deprivation (Egea et al., 2007) through the activation of alpha7 nAChRs (Rosa et al., 2006). PubMed:19293145

p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) View Subject | View Object

In addition, the transport of GLUT1-mediated glucose into the brain is also beneficial to maintaining the integrity of the BBB, thereby ensuring the normal transport of Aβ from brain into blood (Winkler et al. 2015) PubMed:29626319

path(MESH:Fasting) negativeCorrelation a(CHEBI:glucose) View Subject | View Object

We recently discovered that the human brain tau is also modified by O-GlcNAcylation in addition to phosphorylation and that O-GlcNAcylation modulates phosphorylation of tau inversely (Liu et al.,2004a). We found that fasting induced a time-dependent decrease in tau O-GlcNAcylation and concurrent hyperphosphorylation of tau at most of the phosphorylation sites studied. PubMed:16630055

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sec(a(CHEBI:adrenaline)) increases sec(a(CHEBI:glucose)) View Subject | View Object

The release of epinephrine stimulates the body and causes a sudden release of glucose as well as an increase in blood pressure, respiration, and heart rate PubMed:28391535

bp(MESH:Gluconeogenesis) increases a(CHEBI:glucose) View Subject | View Object

A higher glucose requirement is covered, then, by increased glycogenolysis and gluconeogenesis [37, 118]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

bp(MESH:Glycogenolysis) increases a(CHEBI:glucose) View Subject | View Object

A higher glucose requirement is covered, then, by increased glycogenolysis and gluconeogenesis [37, 118]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

p(MGI:Prdx2, pmod(ADPRib)) positiveCorrelation a(CHEBI:glucose) View Subject | View Object

Inclusion of glucose increased the rate of Prx-2 reduction for both day 7 and 35 RBC compared with the reaction without glucose (compare to Fig. 1). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

path(MESH:Hemolysis) negativeCorrelation a(CHEBI:glucose) View Subject | View Object

Without sufficient glucose supply, red blood cells will starve and perish and cytoplasmic components will release. Hemolysis will be the consequence [120]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

path(MESH:Hemolysis) negativeCorrelation a(CHEBI:glucose) View Subject | View Object

Recently, our own collaboration could show that moderate glucose supply reduces hemolysis in rats treated with LPS to induce systemic inflammation [121]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

Out-Edges 6

a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) View Subject | View Object

Primary hippocampal neuron cells at different concentrations (0, 50, 100, 200 lg/ml) of glucose–BSA were incubated together for 24 h, and then thr205- phosphorylated tau was estimated by the western immunoblotting method. Western blot analysis of each experimental group showed that glucose–BSA promoted tau thr205-phosphorylation in a concentration-dependent manner (Fig. 3(a)). In the present study, it was also shown that 100 nM GLP-1 or Ex-4 treatment reduced tau hyperphosphorylation induced by glucose–BSA (Fig. 3(b, c)). PubMed:24183963

Appears in Networks:
Annotations
Uberon
hippocampal formation

a(CHEBI:glucose) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) View Subject | View Object

Western blot analysis of different experimental groups, primary hippocampal neuron cells concurrent treatment with different concentrations (0, 50, 100, 200 lg/ml) of glucose–BSA for 24 h, also showed that glucose–BSA inhibited the phosphorylation of GSK-3b in a concentration-dependent manner (Fig. 4(a)). And 100 nM GLP-1 or Ex-4 can up-regulate phosphorylation of GSK-3b at Ser9, which was decreased by treatment with glucose–BSA (Fig. 4(b, c)). PubMed:24183963

Appears in Networks:
Annotations
Uberon
hippocampal formation

a(CHEBI:glucose) negativeCorrelation path(MESH:Fasting) View Subject | View Object

We recently discovered that the human brain tau is also modified by O-GlcNAcylation in addition to phosphorylation and that O-GlcNAcylation modulates phosphorylation of tau inversely (Liu et al.,2004a). We found that fasting induced a time-dependent decrease in tau O-GlcNAcylation and concurrent hyperphosphorylation of tau at most of the phosphorylation sites studied. PubMed:16630055

Appears in Networks:

a(CHEBI:glucose) positiveCorrelation p(MGI:Prdx2, pmod(ADPRib)) View Subject | View Object

Inclusion of glucose increased the rate of Prx-2 reduction for both day 7 and 35 RBC compared with the reaction without glucose (compare to Fig. 1). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

a(CHEBI:glucose) negativeCorrelation path(MESH:Hemolysis) View Subject | View Object

Without sufficient glucose supply, red blood cells will starve and perish and cytoplasmic components will release. Hemolysis will be the consequence [120]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

a(CHEBI:glucose) negativeCorrelation path(MESH:Hemolysis) View Subject | View Object

Recently, our own collaboration could show that moderate glucose supply reduces hemolysis in rats treated with LPS to induce systemic inflammation [121]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.