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Hippocampus

Name
Hippocampus
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression") View Subject | View Object

However, significant differences in hippocampal gene expression were found in response to MWM performance after prolonged meningeal lymphatic ablation (Extended Data Fig. 5m, n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
MeSH
Mitochondria
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Notably, along with meningeal amyloid-β pathology, we observed an aggravation of brain amyloid-β burden in the hippocampi of 5xFAD mice with dysfunctional meningeal lymphatic vessels (Fig. 3d–g) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels")) View Subject | View Object

However, significant differences in hippocampal gene expression were found in response to MWM performance after prolonged meningeal lymphatic ablation (Extended Data Fig. 5m, n) PubMed:30046111

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus
MeSH
Meninges

act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite) View Subject | View Object

Furthermore, different gene sets that are involved in the regulation of metabolite generation and processing, glycolysis and mitochondrial respiration and oxidative stress were also significantly altered in the hippocampus upon lymphatic ablation and performance of the behaviour test (Extended Data Fig. 5p, s–v) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Hippocampus
MeSH
Meninges

Showing 5 of 603 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.