Title

Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein.

Journal

The Journal of biological chemistry

Volume

281

Issue

None

Pages

9919-24

Date

2006-04-14

Authors

Dorval V | Fraser PE

Both brain proteins were preferentially modified by SUMO1, as compared with SUMO2 or SUMO3. Tau contains two SUMO consensus sequences with Lys(340) as the major sumoylation site. Although both tau and alpha-synuclein are targets for proteasomal degradation, only tau sumoylation was affected by inhibitors of the proteasome pathway. Treatment with the phosphatase inhibitor, okadaic acid, or the microtubule depolymerizing drug, colchicine, up-regulated tau sumoylation.

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