1. Catalog
  2. Citations
  3. PubMed:11943212

PubMed: 11943212

Title
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells.
Journal
FEBS letters
Volume
515
Issue
None
Pages
151-4
Date
2002-03-27
Authors
Buée-Scherrer V | Goedert M

Evidence a27d4e18f9
JSON

The AD2 epitope, which corresponds to phosphorylated S396 and S404 in tau, was generated most effectively by SAPK3/p38gamma and SAPK4/p38delta

p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

Evidence 6f992be3ed
JSON

Immunohistochemical analyses using isoform-selective antibodies demonstrated that MARK4 in a phosphorylated form colocalizes with p-tau Ser262 in granulovacuolar degeneration bodies (GVDs) that progressively accumulate in AD.

a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MARK4, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MARK4, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"granulovacuolar degeneration") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MARK4, pmod(Ph)) positiveCorrelation a(HBP:"granulovacuolar degeneration") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MARK4, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

Evidence cf1fbd7877
JSON

For AT8, which recognises phosphorylated S202 and T205 in tau, SAPK3/p38gamma gave the strongest labelling

p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:

Evidence c3d642301b
JSON

All five SAP kinases generated the AT270 epitope, indicative of phosphorylation of T181 in tau.

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

Appears in Networks:

Evidence fed737d000
JSON

Finally, phosphorylation of S422 in tau, as recognisedby antibody AP422, was generated most e¤ciently by SAPK3/p38gamma, SAPK4/p38delta and SAPK2b/p38beta

p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.