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p(HGNC:MAPK13)

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Entity

Name
MAPK13
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 1

complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) View Subject | View Object

Cdc37 is also required for the stable folding of protein kinases in coordination with Hsp90 (Calderwood, 2015). Many of these kinases are known to phosphorylate tau at sites associated with AD, such as GSK3β and MAPK13 (Taipale et al., 2012; Jin et al., 2016). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

Out-Edges 5

act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Cdc37 is also required for the stable folding of protein kinases in coordination with Hsp90 (Calderwood, 2015). Many of these kinases are known to phosphorylate tau at sites associated with AD, such as GSK3β and MAPK13 (Taipale et al., 2012; Jin et al., 2016). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) View Subject | View Object

All five SAP kinases generated the AT270 epitope, indicative of phosphorylation of T181 in tau. PubMed:11943212

Appears in Networks:

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) View Subject | View Object

The AD2 epitope, which corresponds to phosphorylated S396 and S404 in tau, was generated most effectively by SAPK3/p38gamma and SAPK4/p38delta PubMed:11943212

Appears in Networks:

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) View Subject | View Object

The AD2 epitope, which corresponds to phosphorylated S396 and S404 in tau, was generated most effectively by SAPK3/p38gamma and SAPK4/p38delta PubMed:11943212

Appears in Networks:

p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) View Subject | View Object

Finally, phosphorylation of S422 in tau, as recognisedby antibody AP422, was generated most e¤ciently by SAPK3/p38gamma, SAPK4/p38delta and SAPK2b/p38beta PubMed:11943212

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.